If you’ve been paying attention to health news lately, you’ve probably heard a lot about GLP-1 medications—drugs like semaglutide (Ozempic, Wegovy) that were first designed to treat type 2 diabetes, but are now being hailed as everything from weight-loss miracles to anti-aging game-changers.
And here’s the kicker: about 8% of U.S. adults over 65 have already tried them. That’s a lot of people hoping for better health, more energy, and maybe even a longer life.
But here’s the truth: while GLP-1s can bring huge benefits for older adults, they also come with some very specific risks that deserve attention. Let’s break it down.
The Benefits: Why GLP-1s Sound So Tempting
Research is stacking up in favor of GLP-1 medications for seniors:
Heart and kidney protection. A massive 2024 study of over 83,000 people showed that GLP-1s reduced risks of stroke, improved kidney function, and even lowered overall mortality. For older adults (who are already at higher risk for cardiovascular disease), this is big news.
Lower risk of hospitalization for heart failure. Even mild improvements in heart function can translate into fewer hospital stays.
Potential brain health perks. Early data hints that GLP-1s may help protect against Alzheimer’s and dementia—conditions that affect nearly 1 in 10 people over 65.
With benefits like these, it’s easy to see why some doctors call them a modern-day “fountain of youth.”
The Risks: What Older Adults Need to Watch Out For
Here’s where things get tricky. GLP-1s don’t just melt fat—they can also chip away at muscle and bone, which are already precious resources as we age.
Muscle loss (sarcopenia). After age 30, we naturally lose 3–8% of our muscle mass each decade. GLP-1s speed this up. For adults 65+, that can mean frailty, weakness, and a higher risk of falls.
Bone loss. Thinner, lighter bones mean weaker bones. Less body weight = less stress on the skeleton, and bones need stress to stay strong. That can set the stage for osteoporosis and fractures.
Low blood pressure. If you’re already on blood pressure meds, the weight loss from GLP-1s might push you too low—sometimes causing dizziness or even fainting.
Dehydration. Appetite suppression doesn’t just reduce food intake, it can reduce fluid intake too. Older adults, especially those with kidney disease, are extra vulnerable here.
Protecting Your Health While on GLP-1s
If you and your doctor decide GLP-1 therapy is right for you, the goal is to maximize the benefits while protecting your strength and resilience.
Here are the non-negotiables:
Protein is your friend. Aim for 90–120 grams per day (depending on your body weight). Think eggs, beans, Greek yogurt, chicken, or fish.
Move it or lose it. Resistance training—yes, even light weights or resistance bands—helps preserve muscle mass. Pair it with balance activities like tai chi or yoga to reduce fall risk.
Bone support. Adults over 70 should get at least 1200 mg of calcium and 800 IU of vitamin D daily. Food first, supplements if needed.
Check your meds. If you’re on blood pressure medication, regular monitoring is key. Your doctor may need to adjust your dose.
Hydrate intentionally. Don’t rely on hunger cues—sip water throughout the day, add hydrating foods like fruit and veggies, and check in with your kidneys regularly.
Quick Guide: GLP-1s After 65
Bottom Line
GLP-1 medications can be a powerful tool for older adults—supporting heart, kidney, and even brain health. But they aren’t magic, and they certainly aren’t risk-free.
If you’re over 65 and considering a GLP-1, make sure your healthcare team is looking at the whole picture: your nutrition, your exercise, your bone and muscle health, your medications, and your hydration.
Because real longevity isn’t just about living longer—it’s about living stronger. 💪✨
Ready to Protect Your Strength as You Age?
If you want simple, senior-friendly ways to build muscle, improve balance, and support your body, I’ve created resources designed just for you:
📘 Tai Chi & Qigong- Balancing Exercises for Seniors – gentle, proven moves to improve stability and prevent falls.
📘 5-Minute Resistance Band Exercises for Seniors – quick, effective routines to keep your muscles strong.
📘 13 Easy 5-Minute Yoga Exercises for Seniors – chair-friendly, joint-safe stretches for flexibility and calm.
📘 Balance & Strength 3-in-1 Collection for Seniors – all three guides together for a complete at-home toolkit.
Hi Alison,
Great post and definitely something to keep in mind as we age.
One big thing I’m so happy to have started to do was to train 3 times a week when I retired from the Army. I knew that I needed to keep in shape and my wife was already training with our trainer so it was a good fit for the both of us.
I really liked your post and it did hit home: my family physician didn’t like the readings of my blood sugar levels and we’re now in the process of looking at ways to reduce that. Sitting down with a dietician seems to be the next logical step.
Oh well… I can’t stop the aging part but I sure can help how I feel as I age! Thanks for the post! Cheers!
Wow, this was such a clear breakdown! 🙌 I feel like every time I hear about GLP-1s it’s either “miracle cure!” or “doom and gloom,” so this balanced take was refreshing. Love the practical tips too—protein, movement, hydration—basically the stuff grandma used to nag about, but with a modern twist 😂. It’s good to be reminded that no pill is magic, and you still have to do the unglamorous basics if you want to stay strong and healthy. Great post!
Here’s a simple comment you could leave on that post:
Hey Aliso, this is such a clear breakdown! I keep hearing about these meds but didn’t realize how much they affect muscle and bone too. I like how you gave easy steps to stay strong while on them, super helpful. Thanks for sharing!
Hi Allison – I learn from you every single time! I will say that I have been tempted by the advertisements and the promises of these “miracle drugs.” But I have resisted the temptation until I learn a little bit more and I have discovered that I’m not quite ready for these yet and may not be ready for them ever. But it is tempting, and I will be open should I have the need. Right now I’m trying to focus on my diet and movement. Thank you for sharing your wisdom and expertise as this adds to my research on these potentially beneficial medications.
There’s a lot of hype about creatinine lately, too. Can you do a post on that?
I do take Le-Vel’s form of GLP-1. I don’t feel any different- am feeling well, anyway. My next step is to install a soaking tub in my bathroom and soak every night before bedtime. I’ve been diagnosed with Osteo-Arthritis and know soakings with Epsom Salts will go far for deep healing!!